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oncogene
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Oncogene
Gene that induces a cell to divide abnormally, giving rise to a cancer. Oncogenes arise from mutations in genes (proto-oncogenes) found in all normal cells. In their mutated form, they are found in tumour cells and in viruses that are capable of transforming normal cells to tumour cells. Such viruses are able to insert their oncogenes into the host cell's DNA, causing it to divide uncontrollably. More than one oncogene may be necessary to transform a cell in this way.
In 1989 US scientists J Michael Bishop and Harold Varmus were jointly awarded the Nobel Prize for Physiology or Medicine for their concept of oncogenes, although credit for the discovery was claimed by a French cancer specialist, Dominique Stehelin.
© RM 2009. Helicon Publishing is division of RM.
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